abstract：:In California, Drosophila simulans females from some populations (type W) produce relatively few adult progeny when crossed to males from some other populations (type R), but the productivity of the reciprocal cross is comparable to within-population controls. These two incompatibility types are widespread in North Am...

journal_title：Genetics

authors： Hoffmann AA,Turelli M

更新日期：1988-06-01 00:00:00

abstract：:X chromosome duplications have been used previously to vary the dose of specific regions of the X chromosome to study dosage compensation and sex determination in Caenorhabditis elegans. We show here that duplications suppress and X-linked hypomorphic mutation and elevate the level of activity of an X-linked enzyme, a...

journal_title：Genetics

authors： Meneely PM,Nordstrom KD

更新日期：1988-06-01 00:00:00

abstract：:Mutations in genes of Saccharomyces cerevisiae that code for proteins that interact with beta-tubulin were sought by screening for unlinked mutations that fail to complement mutations in the single beta-tubulin-encoding gene (TUB2). Among the first three noncomplementing mutations examined, two are linked to TUB2 whil...

journal_title：Genetics

authors： Stearns T,Botstein D

更新日期：1988-06-01 00:00:00

abstract：:Recombination in mammalian cells is thought to involve both reciprocal and nonreciprocal modes of exchange, although rigorous proof is lacking due to the inability to recover all products of an exchange. To investigate further the relationship between these modes of exchange, we have analyzed intrachromosomal recombin...

journal_title：Genetics

authors： Bollag RJ,Liskay RM

更新日期：1988-05-01 00:00:00

abstract：:Knowledge of multigenic family organization should provide insight into their mode of evolution. Accordingly, we characterized the 5S ribosomal gene family in the Drosophila melanogaster strain ry506. The 5S genes in this strain display a striking HindIII restriction difference compared to the "standard" D. melanogast...

journal_title：Genetics

authors： Samson ML,Wegnez M

更新日期：1988-04-01 00:00:00

abstract：:The neurogenic loci comprise a small group of genes which are required for proper division between the neural and epidermal pathways of differentiation within the neuroectoderm. Loss of neurogenic gene function results in the misrouting of prospective epidermal cells into neuroblasts. A molecular analysis of the neuro...

journal_title：Genetics

authors： Yedvobnick B,Smoller D,Young P,Mills D

更新日期：1988-03-01 00:00:00

abstract：:This study attempted to assay the zygotic contribution of X chromosome genes to the genetic control of embryonic morphogenesis in Drosophila melanogaster. A systematic screen for X-linked genes which affect the morphology of the embryo was undertaken, employing the phenotype of whole mount embryos as the major screeni...

journal_title：Genetics

authors： Eberl DF,Hilliker AJ

更新日期：1988-01-01 00:00:00

abstract：:Sixty independent UGA suppressors of Saccharomyces cerevisiae have been studied. They are dominant and are divided into 16 groups (loci) by recombination. Suppressors representing these loci are divided into two classes by action spectra; four in class 1 (a broad action spectrum) and 12 in class 2 (a narrow action spe...

journal_title：Genetics

authors： Ono BI,Fujimoto R,Ohno Y,Maeda N,Tsuchiya Y,Usui T,Ishino-Arao Y

更新日期：1988-01-01 00:00:00

abstract：:Sequences of Bronze2 (Bz2), a maize gene which is required for the synthesis of the purple pigment anthocyanin, have been cloned by combining the techniques of transposon tagging and differential hybridization. First, a mutable bz2 allele (bz2-mu1) was recovered from a Mutator line. The mutation was assumed to result ...

journal_title：Genetics

authors： McLaughlin M,Walbot V

更新日期：1987-12-01 00:00:00

abstract：:The mitochondrial genotype of all F(1) female offspring (426 individuals) of a single Drosophila mauritiana female, heteroplasmic for two types of mtDNA (a short and a long genome), was established. All descendants were heteroplasmic. The earliest eggs laid by this female show the cytoplasmic genetic structure of ovar...

journal_title：Genetics

authors： Solignac M,Génermont J,Monnerot M,Mounolou JC

更新日期：1987-12-01 00:00:00

abstract：:The Drosophila melanogaster Gart gene encodes three enzymatic activities in the pathway for purine de novo synthesis. Alternative processing of the primary transcript leads to the synthesis of two overlapping polypeptides. The coding sequence for both polypeptides is interrupted by an intron that contains a functional...

journal_title：Genetics

authors： Henikoff S,Eghtedarzadeh MK

更新日期：1987-12-01 00:00:00

abstract：:Conversion between duplicated genes limits their independent evolution. Models in which conversion frequencies decrease as genes diverge are examined to determine conditions under which genes can "escape" further conversion and hence escape from a gene family. A review of results from various recombination systems sug...

journal_title：Genetics

authors： Walsh JB

更新日期：1987-11-01 00:00:00

abstract：:In order to examine the operation of diversifying selection as the maintenance mechanism of excessive additive genetic variance for viability in southern populations in comparison with northern populations of Drosophila melanogaster, two sets of experiments were conducted using second chromosomes extracted from the Og...

journal_title：Genetics

authors： Takano T,Kusakabe S,Mukai T

更新日期：1987-10-01 00:00:00

abstract：:We have established the DNA sequence and analyzed the transcription and translation products of a series of putative nodulation (nod) genes in Rhizobium meliloti strain 1021. Four loci have been designated nodF, nodE, nodG and nodH. The correlation of transposon insertion positions with phenotypes and open reading fra...

journal_title：Genetics

authors： Fisher RF,Swanson JA,Mulligan JT,Long SR

更新日期：1987-10-01 00:00:00

abstract：:We have analyzed donor and target sites of the mobile element Activator (Ac) that are altered as a result of somatic transposition from the P locus in maize. Previous genetic analysis has indicated that the two mitotic daughter lineages which result from Ac transposition from P differ in their Ac constitution at the P...

journal_title：Genetics

authors： Chen J,Greenblatt IM,Dellaporta SL

更新日期：1987-09-01 00:00:00

abstract：:We have shown that the phenotypes resulting from hypomorphic mutations (causing reduction but not complete loss of function) in two X-linked genes can be used as a genetic assay for X-chromosome dosage compensation in Caenorhabditis elegans between males (XO) and hermaphrodites (XX). In addition we show that recessive...

journal_title：Genetics

authors： Meneely PM,Wood WB

更新日期：1987-09-01 00:00:00

abstract：:Disequilibrium pattern analysis, a general method for analyzing evolutionary events acting on pairs of tightly linked polymorphic loci, is applied to a large sample of Danish individuals typed for A and B loci of the HLA (human leukocyte antigen) system. Cases of selection on particular haplotypes are revealed from pa...

journal_title：Genetics

authors： Klitz W,Thomson G

更新日期：1987-08-01 00:00:00

abstract：:Fifteen classical linkage groups were identified in two salmonid species (Salmo trutta and Salmo gairdneri) and three fertile, interspecific hybrids (S. gairdneri X Salmo clarki, Salvelinus fontinalis X Salvelinus namaycush and S. fontinalis X Salvelinus alpinus) by backcrossing multiply heterozygous individuals. Thes...

journal_title：Genetics

authors： Johnson KR,Wright JE Jr,May B

更新日期：1987-08-01 00:00:00

abstract：:Deficiencies encompassing part or all of the X heterochromatin of Drosophila melanogaster have been linked to three abnormalities in male meiosis and spermatogenesis: X-Y nondisjunction, skewed sperm recovery ratios favoring sperm with reduced chromatin content, and sterility in males carrying either a Y-autosome tran...

journal_title：Genetics

authors： McKee B,Lindsley DL

更新日期：1987-07-01 00:00:00

abstract：:We describe here a new variant of transposon Tn10 especially adapted for transposon analysis of cloned yeast genes; it can equally well be used for analysis of prokaryotic genes. We have applied this element to analysis of the LEU2, RAD50, and CDC48 genes of Saccharomyces cerevisiae. This transposon, nicknamed mini-Tn...

journal_title：Genetics

authors： Huisman O,Raymond W,Froehlich KU,Errada P,Kleckner N,Botstein D,Hoyt MA

更新日期：1987-06-01 00:00:00

abstract：:The determination of segment identity in Drosophila melanogaster appears to be controlled by a small number of genes. In order to identity new components in the process, we have systematically screened the autosomal complement for loci that show a dosage-dependent interaction with mutations in previously characterized...

journal_title：Genetics

authors： Kennison JA,Russell MA

更新日期：1987-05-01 00:00:00

abstract：:Mating type interconversion in Saccharomyces cerevisiae occurs by transposition of copies of the a or alpha mating type cassettes from inactive loci, HML and HMR, to an active locus, MAT. The lack of expression of the a and alpha genes at the silent loci results from repression by trans-acting regulators encoded by SI...

journal_title：Genetics

authors： Rine J,Herskowitz I

更新日期：1987-05-01 00:00:00

abstract：:Rates of molecular evolution at some loci are more irregular than described by simple Poisson processes. Three situations under which molecular evolution would not follow simple Poisson processes are reevaluated from the viewpoint of the neutrality hypothesis: concomitant or multiple substitutions in a gene, fluctuati...

journal_title：Genetics

authors： Takahata N

更新日期：1987-05-01 00:00:00

abstract：:Following transformation of a Drosophila melanogaster true M strain with an autonomous P element, six lines were established and monitored for their molecular and phenotypic properties during a 4-yr period. The number of P elements increased with time in all the lines but the rate of increase differed among lines. Fur...

journal_title：Genetics

authors： Daniels SB,Clark SH,Kidwell MG,Chovnick A

更新日期：1987-04-01 00:00:00

abstract：:Heteroduplexes with single base pair mismatches of known sequence were prepared by annealing separated strands of bacteriophage lambda DNA and used to transfect Escherichia coli. A series of transition (G:T and A:C) and transversion (G:A and C:T) mismatches located throughout most of the bacteriophage lambda cI gene h...

journal_title：Genetics

authors： Jones M,Wagner R,Radman M

更新日期：1987-04-01 00:00:00

abstract：:We demonstrate that the previously described gene Androgen binding protein (Abp; Dlouhy and Karn, 1984) codes for the Alpha subunit of ABP and rename the locus Androgen binding protein alpha (Abpa). A study of recombinant inbred strains demonstrates that Abpa is located on chromosome 7 near Glucose phosphate isomerase...

journal_title：Genetics

authors： Dlouhy SR,Taylor BA,Karn RC

更新日期：1987-03-01 00:00:00

abstract：:Pairwise linkage disequilibrium values (D) were estimated for 14 allozyme loci in two natural populations of lodgepole pine (Pinus contorta ssp. latifolia). Maternal multilocus genotypes were inferred from samples of (haploid) megagametophytic seed-endosperms. Coupling/repulsion double heterozygotes were distinguished...

journal_title：Genetics

authors： Epperson BK,Allard RW

更新日期：1987-02-01 00:00:00

abstract：:We have selected 210 mutants able to grow on sucrose in the presence of 2-deoxyglucose. We identified recessive mutations in three major complementation groups that cause constitutive (glucose-insensitive) secreted invertase synthesis. Two groups comprise alleles of the previously identified HXK2 and REG1 genes, and t...

journal_title：Genetics

authors： Neigeborn L,Carlson M

更新日期：1987-02-01 00:00:00

abstract：:The presence of at least ten mouse LDH-A pseudogenes was demonstrated in the genomic blot analysis, and four different processed pseudogenes have thus far been isolated and characterized. In this report, the nucleotide sequences to two different mouse lactate dehydrogenase-A processed pseudogenes, M11 and M14, were de...

journal_title：Genetics

authors： Fukasawa KM,Tanimura M,Sakai I,Sharief FS,Chung FZ,Li SS

更新日期：1987-01-01 00:00:00

abstract：:The occurrence and patterns of linkage disequilibrium between an inversion and allozymic loci within it or nearby have been used in attempts to discriminate among different hypotheses for the maintenance of variability. The interpretation of the data on the best-documented case, that of the nonrandom association betwe...

journal_title：Genetics

authors： Malpica JM,Vassallo JM,Frías A,Fuentes-Bol F

更新日期：1987-01-01 00:00:00

abstract：:Laboratory strains of mice are thought to be derived from wild populations of Mus domesticus. Many instances of non-domesticus genetic information fixed in these strains have been described, however, and the amount of strain-to-strain genetic variation exceeds that found in wild domesticus populations. In order to est...

journal_title：Genetics

authors： Blank RD,Campbell GR,D'Eustachio P

更新日期：1986-12-01 00:00:00

abstract：:Differentiation in morphometric traits among experimental populations of the housefly subjected to an experimental bottleneck was examined for replicate lines founded with one, four or 16 pairs of flies. Differentiation among lines within a bottleneck size was significantly greater than predicted by drift in relation ...

journal_title：Genetics

authors： Bryant EH,Combs LM,McCommas SA

更新日期：1986-12-01 00:00:00

abstract：:Gene mapping studies to determine the order of alpha- and beta-interferon (Ifa, Ifb), aminolevulinate dehydratase (Lv), and alpha-1 acid glycoprotein-1 and -2 (Orm-1, Orm-2) relative to each other and to the reference genes brown (b), B-cell maturation factor responsiveness (Bmfr-1), and major urinary protein-1 (Mup-1...

journal_title：Genetics

authors： Nadeau JH,Berger FG,Kelley KA,Pitha PM,Sidman CL,Worrall N

更新日期：1986-12-01 00:00:00

abstract：:The parentals of the interspecific cross Cucurbita maxima xC. ecuadorensis had different isozyme phenotypes for 12 enzyme systems. Characterization of the systems demonstrated that the expression and intracellular distribution of the isozymes were similar to those in other plant taxa; however, a considerable number of...

journal_title：Genetics

authors： Weeden NF,Robinson RW

更新日期：1986-10-01 00:00:00

abstract：:Two alternate transcripts of the single copy Alcohol dehydrogenase (Adh) gene accumulate with developmental specificity in all of 12 species of Hawaiian picture-winged Drosophila which have been examined. Relative to the paradigm species D. affinidisjuncta, the Adh transcript normally restricted to larvae is found to ...

journal_title：Genetics

authors： Rowan RG,Dickinson WJ

更新日期：1986-10-01 00:00:00

abstract：:We have tested the hypothesis that genetic differences among conspecific populations may result in diverse responses to selection, using natural populations of Drosophila melanogaster. Selection for ethanol tolerance in a tube measuring knockdown resistance was imposed on five West Coast populations. In 24 generations...

journal_title：Genetics

authors： Cohan FM,Hoffmann AA

更新日期：1986-09-01 00:00:00

abstract：:In experiments with directional selection on a quantitative character a "reversed response" to selection is occasionally observed, when selection of individuals for a higher (lower) value of the character results in a lower (higher) value of the character among their offspring. A sudden change in environments or rando...

journal_title：Genetics

authors： Gimelfarb A

更新日期：1986-09-01 00:00:00

abstract：:Results of immunogenetic, immunochemical and physicochemical investigations on two serum allotypes of swine are reported. The allotypes, designated Lpr1 and Lpr2, have been identified by specific alloprecipitins in agar gel. Genetic studies indicate that the allotypes are specified by two codominant autosomal allelic ...

journal_title：Genetics

authors： Rapacz J,Hasler-Rapacz J,Kuo WH

更新日期：1986-08-01 00:00:00

abstract：:Restriction fragment length polymorphisms in mitochondrial DNA (mtDNA) were used to reconstruct evolutionary relationships of conspecific populations in four species of freshwater fish-Amia calva, Lepomis punctatus, L. gulosus, and L. microlophus. A suite of 14-17 endonucleases was employed to assay mtDNAs from 305 sp...

journal_title：Genetics

authors： Bermingham E,Avise JC

更新日期：1986-08-01 00:00:00

abstract：:Hepatic glucocorticoid receptor binding activity was measured in A/J, C57BL/6J, their F1 reciprocal crosses and their F1 recombinant inbred (RI) lines. The glucocorticoid binding capacity was measured in Hepes buffer and Hepes buffer plus dithiothreitol (DTT). The A/J parental strain showed higher levels, and a greate...

journal_title：Genetics

authors： Liu SL,Erickson RP

更新日期：1986-07-01 00:00:00